The combination of mutations affecting the chico, E(z) and puc genes may be promising due to the summation of the effects arising from their change. The first is directly related to energy metabolism, during which reactive oxygen species are formed, which have a toxic effect on the cells of the body. At the same time, a mutation in the chico gene reduces the energy consumption for the course of biochemical reactions, which reduces the intensity of the appearance of ROS. In turn, the mutation in the puc gene allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier, while the mutation in the E(z) gene increases the body's resistance to oxidative stress, caused by ROS molecules that have escaped neutralization.

The promise of the combination of chico and Indy genes is due to the influence of genes on the same global process - energy metabolism - and in a similar way: mutations in the future can simultaneously reduce energy costs for the implementation of metabolic processes and reduce their speed. Potentially, this can significantly increase the economy of the body's resources and thereby prolong life.

The promise of the combination of chico and Indy genes is due to the influence of genes on the same global process - energy metabolism - and in a similar way: mutations in the future can simultaneously reduce energy costs for the implementation of metabolic processes and reduce their speed. Potentially, this can significantly increase the economy of the body's resources and thereby prolong life.

The potential benefit from the combination of the puc and E(z) genes may be associated with a marked increase in the body's resistance to oxidative stress. As mentioned above, a mutation in the rice gene leads to a more effective elimination of toxic reactive oxygen species (ROS), while a mutation in the E(z) gene regulates the elimination of the effects of exposure. Thus, the rice mutation will reduce the effect of synthesized reactive oxygen species, and the E(z) gene mutation should neutralize the negative consequences.

The potential benefit from the combination of the puc and E(z) genes may be associated with a marked increase in the body's resistance to oxidative stress. As mentioned above, a mutation in the rice gene leads to a more effective elimination of toxic reactive oxygen species (ROS), while a mutation in the E(z) gene regulates the elimination of the effects of exposure. Thus, the rice mutation will reduce the effect of synthesized reactive oxygen species, and the E(z) gene mutation should neutralize the negative consequences.

It has been suggested that the immune system plays a key role in determining lifespan. In studies of the effectiveness of the innate immune system in fruit flies carrying life-extending mutations in the puc and chico genes, it was found that both puc and chico mutated fruit flies showed an almost three-fold increase in survival after infection with gram-positive or gram-negative bacteria. At the same time, heterozygous puc animals, as well as chico homozygous and heterozygous animals, have increased resistance to pathogens. Thus, the combination of these mutations may allow the potentiation of resistance to infections through different signaling systems, however, the exact mechanism by which these interventions can provide a slowdown in age-related changes in the body, as well as aging itself, is still widely discussed.

It has been suggested that the immune system plays a key role in determining lifespan. In studies of the effectiveness of the innate immune system in fruit flies carrying life-extending mutations in the puc and chico genes, it was found that both puc and chico mutated fruit flies showed an almost three-fold increase in survival after infection with gram-positive or gram-negative bacteria. At the same time, heterozygous puc animals, as well as chico homozygous and heterozygous animals, have increased resistance to pathogens. Thus, the combination of these mutations may allow the potentiation of resistance to infections through different signaling systems, however, the exact mechanism by which these interventions can provide a slowdown in age-related changes in the body, as well as aging itself, is still widely discussed.

The combination of mutations affecting the chico, Indy and puc genes may be promising due to the summation of the effects arising from their change. The first two are directly related to energy metabolism, during which reactive oxygen species are formed that have a toxic effect on body cells. At the same time, a mutation in the Indy gene slows down metabolic processes, thereby reducing the production of ROS, and a mutation in chico reduces energy costs for the course of biochemical reactions, which also reduces the intensity of the appearance of ROS. In turn, the puc mutation allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier.

A mutation in the chico gene reduces the energy required to carry out a biochemical reaction, which hypothetically can form an effect similar to starvation. Yes, in laboratory conditions this led to an increase in life expectancy, but a mutation in the E(z) gene, which increases the body's resistance to nutrient deficiency conditions, in this case would be more than appropriate.

A mutation in the chico gene reduces the energy required to carry out a biochemical reaction, which hypothetically can form an effect similar to starvation. Yes, in laboratory conditions this led to an increase in life expectancy, but a mutation in the E(z) gene, which increases the body's resistance to nutrient deficiency conditions, in this case would be more than appropriate.

The combination of mutations affecting the Indy and puc genes may be promising due to the summation of the effects arising from their change. The first of them is directly related to energy metabolism, during which reactive oxygen species are formed, which have a toxic effect on the cells of the body. At the same time, a mutation in the Indy gene slows down metabolic processes, thereby reducing the production of ROS. In turn, the puc mutation allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops, despite the mutation described earlier.

The combination of mutations affecting the Indy and puc genes may be promising due to the summation of the effects arising from their change. The first of them is directly related to energy metabolism, during which reactive oxygen species are formed, which have a toxic effect on the cells of the body. At the same time, a mutation in the Indy gene slows down metabolic processes, thereby reducing the production of ROS. In turn, the puc mutation allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops, despite the mutation described earlier.

The combination of mutations affecting the chico, Indy and puc genes may be promising due to the summation of the effects arising from their change. The first two are directly related to energy metabolism, during which reactive oxygen species are formed that have a toxic effect on body cells. At the same time, a mutation in the Indy gene slows down metabolic processes, thereby reducing the production of ROS, and a mutation in chico reduces energy costs for the course of biochemical reactions, which also reduces the intensity of the appearance of ROS. In turn, the puc mutation allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier.

The combination of mutations affecting the chico, Indy and puc genes may be promising due to the summation of the effects arising from their change. The first two are directly related to energy metabolism, during which reactive oxygen species are formed that have a toxic effect on body cells. At the same time, a mutation in the Indy gene slows down metabolic processes, thereby reducing the production of ROS, and a mutation in chico reduces energy costs for the course of biochemical reactions, which also reduces the intensity of the appearance of ROS. In turn, the puc mutation allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier.

The combination of mutations affecting the chico, E(z) and puc genes may be promising due to the summation of the effects arising from their change. The first is directly related to energy metabolism, during which reactive oxygen species are formed, which have a toxic effect on the cells of the body. At the same time, a mutation in the chico gene reduces the energy consumption for the course of biochemical reactions, which reduces the intensity of the appearance of ROS. In turn, the mutation in the puc gene allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier, while the mutation in the E(z) gene increases the body's resistance to oxidative stress, caused by ROS molecules that have escaped neutralization.

The combination of mutations affecting the chico, Indy and puc genes may be promising due to the summation of the effects arising from their change. The first two are directly related to energy metabolism, during which reactive oxygen species are formed that have a toxic effect on body cells. At the same time, a mutation in the Indy gene slows down metabolic processes, thereby reducing the production of ROS, and a mutation in chico reduces energy costs for the course of biochemical reactions, which also reduces the intensity of the appearance of ROS. In turn, the puc mutation allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier.

The combination of mutations affecting the chico, Indy and puc genes may be promising due to the summation of the effects arising from their change. The first two are directly related to energy metabolism, during which reactive oxygen species are formed that have a toxic effect on body cells. At the same time, a mutation in the Indy gene slows down metabolic processes, thereby reducing the production of ROS, and a mutation in chico reduces energy costs for the course of biochemical reactions, which also reduces the intensity of the appearance of ROS. In turn, the puc mutation allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier.

The combination of mutations affecting the chico, Indy and puc genes may be promising due to the summation of the effects arising from their change. The first two are directly related to energy metabolism, during which reactive oxygen species are formed that have a toxic effect on body cells. At the same time, a mutation in the Indy gene slows down metabolic processes, thereby reducing the production of ROS, and a mutation in chico reduces energy costs for the course of biochemical reactions, which also reduces the intensity of the appearance of ROS. In turn, the puc mutation allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier.

The combination of mutations affecting the chico, E(z) and puc genes may be promising due to the summation of the effects arising from their change. The first is directly related to energy metabolism, during which reactive oxygen species are formed, which have a toxic effect on the cells of the body. At the same time, a mutation in the chico gene reduces the energy consumption for the course of biochemical reactions, which reduces the intensity of the appearance of ROS. In turn, the mutation in the puc gene allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier, while the mutation in the E(z) gene increases the body's resistance to oxidative stress, caused by ROS molecules that have escaped neutralization.

The combination of mutations affecting the chico, E(z) and puc genes may be promising due to the summation of the effects arising from their change. The first is directly related to energy metabolism, during which reactive oxygen species are formed, which have a toxic effect on the cells of the body. At the same time, a mutation in the chico gene reduces the energy consumption for the course of biochemical reactions, which reduces the intensity of the appearance of ROS. In turn, the mutation in the puc gene allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier, while the mutation in the E(z) gene increases the body's resistance to oxidative stress, caused by ROS molecules that have escaped neutralization.

The combination of mutations affecting the chico, E(z) and puc genes may be promising due to the summation of the effects arising from their change. The first is directly related to energy metabolism, during which reactive oxygen species are formed, which have a toxic effect on the cells of the body. At the same time, a mutation in the chico gene reduces the energy consumption for the course of biochemical reactions, which reduces the intensity of the appearance of ROS. In turn, the mutation in the puc gene allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier, while the mutation in the E(z) gene increases the body's resistance to oxidative stress, caused by ROS molecules that have escaped neutralization.

The combination of mutations affecting the chico, E(z) and puc genes may be promising due to the summation of the effects arising from their change. The first is directly related to energy metabolism, during which reactive oxygen species are formed, which have a toxic effect on the cells of the body. At the same time, a mutation in the chico gene reduces the energy consumption for the course of biochemical reactions, which reduces the intensity of the appearance of ROS. In turn, the mutation in the puc gene allows the body to more effectively neutralize toxic oxygen molecules, thereby eliminating the effect that still develops despite the mutation described earlier, while the mutation in the E(z) gene increases the body's resistance to oxidative stress, caused by ROS molecules that have escaped neutralization.